Myelin Activation – Multiple Sclerosis
Understanding Myelin and Multiple Sclerosis
Myelin is a fatty insulating sheath that wraps around nerve fibers (axons) in the central nervous system. It enables rapid and efficient transmission of electrical signals between the brain, spinal cord, and the rest of the body.
In Multiple Sclerosis (MS), the immune system mistakenly attacks myelin, causing inflammation, demyelination (loss of myelin), and eventual nerve damage. This leads to disrupted nerve signaling, resulting in symptoms such as fatigue, muscle weakness, vision problems, balance issues, cognitive difficulties, and progressive disability.
Promoting myelin production and repair (remyelination) is a major focus in MS research. Enhancing myelin-related gene expression could help restore the protective sheath around nerves and improve neurological function.
The Role of Myelin Activation
Activating genes responsible for myelin production and maintenance can:
+ Improve nerve insulation and signal transmission
+ Support remyelination after immune damage
+ Protect neurons from further degeneration
+ Potentially reduce symptoms and slow disease progression in Multiple Sclerosis
Our Research Approach
We are focusing on the discovery of novel myelin activators using our proprietary platform:
High-Throughput Screening (HTS)
for Small-Molecule Activators
Using our advanced GFP-based promoter-reporter assays in human cell cultures, we screen thousands of natural and synthetic compounds to identify those that significantly increase JAM2 gene expression.
Promising molecules will be prioritized for further development as potential nutraceutical or pharmaceutical candidates.
Partnership Opportunities
We offer licensing of discovered compounds, custom research, and technology transfer for all three approaches.
HTS Screening Project: Start at $40,000 – $150,000 + 5% royalty
Gene Therapy Development: Custom pricing (typically $1M – $2M) + 5% royalty
Full technology transfer and offshore lab setup available
Head Office
Tampa
Florida, US
Call Now
312-730-2562
786-307-1256
Email Us
dr.nikolic@ufl.edu