15-Lipoxygenase Inhibition – Mitochondrial & Lipid Health
Understanding 15-Lipoxygenase
and Its Impact
15-Lipoxygenase (15-LOX) is an enzyme that plays a key role in the metabolism of polyunsaturated fatty acids. It generates bioactive lipid mediators that can promote oxidative stress and low-grade inflammation.
Elevated 15-LOX activity is associated with impaired mitochondrial function, inefficient lipid conversion, increased oxidative damage, and metabolic dysfunction. These effects can contribute to fatigue, reduced cellular energy production, cardiovascular issues, and accelerated aging processes.
Inhibiting 15-LOX helps reduce harmful lipid byproducts, protects mitochondria (the powerhouses of the cell), and supports healthier lipid metabolism and energy balance.
The Role of
15-Lipoxygenase Inhibition
By inhibiting 15-LOX, we can decrease oxidative stress on mitochondria and improve the efficient conversion and utilization of lipids.
This approach shows strong potential for:
+ Enhancing mitochondrial performance and cellular energy
+ Reducing inflammation caused by lipid metabolites
+ Supporting metabolic health and healthy aging
Our Research Approach
We are focusing on one primary strategy to discover effective 15-Lipoxygenase inhibitors:
High-Throughput Screening (HTS)
for Small-Molecule Inhibitors
Using our advanced GFP-based promoter-reporter assays in human cell cultures, we screen thousands of natural and synthetic compounds to identify potent and selective inhibitors of 15-LOX gene expression and activity. This platform allows us to rapidly discover promising nutraceutical or pharmaceutical candidates that can protect mitochondria and optimize lipid metabolism.
Partnership Opportunities
We offer licensing of discovered compounds, custom research, and technology transfer for all three approaches.
HTS Screening Project: Start at $40,000 – $150,000 + 5% royalty
Gene Therapy Development: Custom pricing (typically $1M – $2M) + 5% royalty
Full technology transfer and offshore lab setup available
Head Office
Tampa
Florida, US
Call Now
312-730-2562
786-307-1256
Email Us
dr.nikolic@ufl.edu